BH

Zelenko Protocol[1]

Treatment Plan for Patients with Covid-19 symptoms

Prehospital Management

Dr. Vladimir Zelenko

Twitter: @zev_dr

Fundamental Principles

Treat patients based on clinical suspicion as soon as possible, preferably within the first 5 days of symptoms. Perform PCR testing, but do not withhold treatment pending results.

Risk Stratify Patients

Low risk patient - Younger than 45, no comorbidities, and clinically stable

High risk patient - Older than 45, younger than 45 with comorbidities, or clinically unstable

Treatment Options

Low risk patients - over the counter options:

1. Elemental Zinc 50mg 1 time a day for 7 days[2]

2. Quercetin 500mg 2 times a day for 7 days[3] or

Epigallocatechin-gallate (EGCG) 400mg 1 time a day for 7 days[4]

3. Vitamin C 1000mg 1 time a day for 7 days

4. Rest, oral fluids and close follow up with doctor

High risk patients

1. Elemental Zinc 50mg 1 time a day for 7 days

2. Hydroxychloroquine (HCQ) 200mg 2 times a day for 7 days

If HCQ not available, Quercetin 500mg 3 times a day for 7 days or

EGCG 400mg 2 times a day for 7 days

3. Azithromycin 500mg 1 time a day for 5 days or

Doxycycline 100mg 2 times a day for 7 days

4. Vitamin C 1000mg 1 time a day for 7 days

5. Rest, oral fluids and close followup with doctor

Additional treatment options. Should be uniquely custom tailored for every patient.

1. Ivermectin 6mg 2 times a day for 1 day[5]

2. Budesonide 1mg/2cc solution via nebulizer 2 times a day for 7 days[6]

3. Dexamethasone 6mg 1 time a day for 7 days[7]

4. Blood thinners (i.e. Lovenox)[8]

5. Home Oxygen

6. Home IV fluids

IF POSSIBLE, KEEP PATIENTS OUT OF THE HOSPITAL

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[1] https://www.preprints.org/manuscript/202007.0025/v1

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365891/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318306/

[4] https://pubs.acs.org/doi/10.1021/jf5014633

[5] https://www.sciencedirect.com/science/article/pii/S0166354220302011

[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392554/

[7] https://www.nejm.org/doi/full/10.1056/NEJMoa2021436

[8]https://www.onlinejacc.org/content/76/1/122?_ga=2.33698596.423106752.1597365568-1776897998.1597365568